Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic Intra-p53 Family Member Interactions in Human Cancers

31 Mar 2016

Abstract excerpt

The p53 gene family members p53, p73, and p63 display several isoforms derived from the presence of internal promoters and alternative splicing events. They are structural homologs but hold peculiar functional properties. p53, p73, and p63 are tumor suppressor genes that promote differentiation, senescence, and apoptosis. p53, unlike p73 and p63, is frequently mutated in cancer often displaying oncogenic "gain of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27066457
DOI: 10.3389/fonc.2016.00077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic Intra-p53 Family Member Interactions in Human CancersPMID 27066457Read ↗

p63 and p73 in human cancer: defining the network.Semantic proximity Read ↗

Role of p53 family members p73 and p63 in human hematological malignanciesSemantic proximity Read ↗

The Diverse Functions of Mutant 53, Its Family Members and Isoforms in Cancer.Semantic proximity Read ↗

A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunitySemantic proximity Read ↗

Family feud in chemosensitvity: p73 and mutant p53.Semantic proximity Read ↗

TP53 family members and human cancers.Semantic proximity Read ↗

p53 family members in cancer diagnosis and treatment.Semantic proximity Read ↗

p53 Isoforms as Cancer Biomarkers and Therapeutic TargetsSemantic proximity Read ↗

Dual Role of p73 in Cancer Microenvironment and DNA Damage ResponseSemantic proximity Read ↗

p53 Family isoforms.Semantic proximity Read ↗

Mutant p53 in Cancer Progression and Targeted TherapiesSemantic proximity Read ↗

The p53 family member p73 in the regulation of cell stress responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.