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Article

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2014

Corces-Zimmerman M Ryan, Hong Wan-Jen, Weissman Irving L, Medeiros Bruno C, Majeti Ravindra

Abstract excerpt

Cancer is widely characterized by the sequential acquisition of genetic lesions in a single lineage of cells. Our previous studies have shown that, in acute myeloid leukemia (AML), mutation acquisition occurs in functionally normal hematopoietic stem cells (HSCs). These preleukemic HSCs harbor some, but not all, of the mutations found in the leukemic cells. We report here the identification of patterns of...

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Share to Antigens, CD34
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Flow Cytometry

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

Share to Models, Biological

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Identifiers

PMID: 24550281
DOI: 10.1073/pnas.1324297111
PMCID: PMC3932921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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