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Article

Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.

Molecular biology of the cell - 1 Apr 2004

Lin Jue, Smith Dana L, Blackburn Elizabeth H

Abstract excerpt

Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence combinations at template positions 474-476 of the yeast telomerase RNA, TLC1. Mutants contained faithfully incorporated template mutations, as well as misincorporated sequences in telomeres, a phenotype not previously reported for Saccharomyces cerevisiae...

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Identifiers

PMID: 14742705
DOI: 10.1091/mbc.e03-10-0740
PMCID: PMC379261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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