Article
Macrophage migration inhibitory factor: association of -794 CATT5-8 and -173 G>C polymorphisms with TNF-α in systemic lupus erythematosus.
Human immunology - 1 May 2014
De la Cruz-Mosso U, Bucala R, Palafox-Sánchez C A, Parra-Rojas I, Padilla-Gutiérrez J R, Pereira-Suárez A L, Rangel-Villalobos H, Vázquez-Villamar M, Angel-Chávez L I, Muñoz-Valle J F
Abstract excerpt
Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory cytokine associated with the pathogenesis of autoimmune inflammatory diseases. There is evidence that MIF functions in a positive feedback loop with TNF-α that could perpetuate the inflammatory process in systemic lupus erythematosus (SLE). In this case-control study we investigated whether commonly occurring functional MIF polymorphisms...
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