Article
Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy.
American journal of respiratory and critical care medicine - 1 May 2004
Hizawa Nobuyuki, Yamaguchi Elsuro, Takahashi Daisuke, Nishihira Jun, Nishimura Masaharu
Abstract excerpt
Macrophage migration inhibitory factor (MIF) is a pleiotrophic lymphocyte and macrophage cytokine; it is likely to play an important role in innate immunity. Genome-wide search for atopy susceptibility genes recently identified human chromosome 22q11, where the gene encoding MIF resides, as a region of interest for atopic traits. Both the -173G/C and -794 [CATT]5-8 repeat polymorphisms in the MIF promoter region...
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