MIF functional polymorphisms (-794 CATT5-8 and -173 G>C) are associated with MIF serum levels, severity and progression in male multiple sclerosis from western Mexican population.

doi:10.1016/j.jneuroim.2018.04.006

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MIF functional polymorphisms (-794 CATT5-8 and -173 G>C) are associated with MIF serum levels, severity and progression in male multiple sclerosis from western Mexican population.

Journal of neuroimmunology - 15 Jul 2018

Castañeda-Moreno V A, De la Cruz-Mosso U, Torres-Carrillo N, Macías-Islas M A, Padilla-De la Torre O, Mireles-Ramírez M A, González-Pérez O, Ruiz-Sandoval J L, Huerta M, Trujillo X, Ortuño-Sahagún D, Muñoz-Valle J F

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is a cytokine associated with tissue damage in multiple autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis. The role of MIF in multiple sclerosis (MS) and the contribution of its polymorphisms are unknown in our population. Therefore, we decided to investigate the genetic association of -794 CATT5-8 (rs5844572) and...

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PMID: 29661540
DOI: 10.1016/j.jneuroim.2018.04.006

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