Article
Nanog-independent reprogramming to iPSCs with canonical factors.
Stem cell reports - 11 Feb 2014
Carter Ava C, Davis-Dusenbery Brandi N, Koszka Kathryn, Ichida Justin K, Eggan Kevin
Abstract excerpt
It has been suggested that the transcription factor Nanog is essential for the establishment of pluripotency during the derivation of embryonic stem cells and induced pluripotent stem cells (iPSCs). However, successful reprogramming to pluripotency with a growing list of divergent transcription factors, at ever-increasing efficiencies, suggests that there may be many distinct routes to a pluripotent state. Here,...
Topics
- Animals
- Cell Differentiation
- Cellular Reprogramming
- Chimera
- Cluster Analysis
- Female
- Fibroblasts
- Gene Expression
- Gene Expression Profiling
- Gene Knockdown Techniques
- Homeodomain Proteins