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Article

Effects of Ectopic Nanog and Oct4 Overexpression on Mesenchymal Stem Cells

22 Dec 2008

Abstract excerpt

Mesenchymal stem cells (MSCs) represent a source of pluripotent cells that are already in various phases of clinical application. However, the use of MSCs in tissue engineering has been hampered largely due to their limitations, including low proliferation, finite life span, and gradual loss of their stem cell properties during ex vivo expansion. Nanog and Oct4 are key transcription factors essential to the...

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PMID: 19102659
DOI: 10.1089/scd.2008.0335

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