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Article

Dexrazoxane prevents the development of the impaired cardiac phenotype in caveolin-1-disrupted mice.

Journal of cardiovascular pharmacology - 1 Jun 2013

Polanski Anne-Katrin, Ebner Annette, Ebner Bernd, Hofmann Anja, Steinbronn Nadine, Brandt Aljoscha, Forkmann Mathias, Tausche Anne-Kathrin, Morawietz Henning, Strasser Ruth H, Wunderlich Carsten

Abstract excerpt

: Caveolin-1-deficient (cav1) mice display a severely diseased cardiac phenotype with systolic and diastolic heart failure. Accumulating evidence supports a causative role of uncoupled endothelial nitric oxide synthase in the development of these abnormalities. Interestingly, a similar molecular mechanism was proposed for anthracycline-induced cardiomyopathy. Currently, dexrazoxane is approved for the prevention...

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PMID: 23474841
DOI: 10.1097/FJC.0b013e31828de47c

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