Article
One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor.
Scientific reports - 16 Mar 2017
Su Dongru, Wang Min, Ye Chenli, Fang Jiahui, Duan Yanhui, Zhang Zhenghong, Hua Qiuhong, Shi Changjie, Zhang Lihong, Zhang Ru, Xie Xin
Abstract excerpt
G protein-coupled receptors (GPCRs) are important modulators of many physiological functions and excellent drug targets for many diseases. However, to study the functions of endogenous GPCRs is still a challenging task, partially due to the low expression level of GPCRs and the lack of highly potent and selective GPCR antibodies. Overexpression or knock-in of tagged GPCRs, or knockout of specific GPCRs in mice,...
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