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Article

Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion.

Aging - 1 Jan 2014

Zhu Chen-Tseh, Chang Chengyi, Reenan Robert A, Helfand Stephen L

Abstract excerpt

Natural selection acts to maximize reproductive fitness. However, antagonism between life span and reproductive success frequently poses a dilemma pitting the cost of fecundity against longevity. Here, we show that natural populations of Drosophila melanogaster harbor a Hoppel transposon insertion variant in the longevity gene Indy (I'm not dead yet), which confers both increased reproduction and longevity...

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Source

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Identifiers

PMID: 24519859
DOI: 10.18632/aging.100634
PMCID: PMC3927810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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