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Article

Context-dependent genetic architecture of Drosophila life span.

PLoS biology - 1 Mar 2020

Huang Wen, Campbell Terry, Carbone Mary Anna, Jones W Elizabeth, Unselt Desiree, Anholt Robert R H, Mackay Trudy F C

Abstract excerpt

Understanding the genetic basis of variation in life span is a major challenge that is difficult to address in human populations. Evolutionary theory predicts that alleles affecting natural variation in life span will have properties that enable them to persist in populations at intermediate frequencies, such as late-life-specific deleterious effects, antagonistic pleiotropic effects on early and late-age fitness...

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Identifiers

PMID: 32134916
DOI: 10.1371/journal.pbio.3000645
PMCID: PMC7077879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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