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Article

Transposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster.

PLoS biology - 1 Mar 2026

Marion Sarah B, Focht Katrina, Hamid Iman, Iversen Edwin S, John Hannah, Manzano-Winkler Brenda, Navarra Amber, Pangare Saniya, Zarei Mehrnaz, Noor Mohamed A F

Abstract excerpt

Recessive lethal mutations are widespread across studied species, with estimates suggesting that each individual carries at least one. Numerous lethal alleles persist in wild populations at higher frequencies than expected given their extreme deleterious nature. Though these findings spurred historical debate whether classical balancing selection maintains some lethal alleles at elevated frequencies (versus...

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Identifiers

PMID: 41805845
DOI: 10.1371/journal.pbio.3003467
PMCID: PMC12974806

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