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COLD-PCR Technologies in the Area of Personalized Medicine: Methodology and Applications.

Molecular diagnosis & therapy - 1 Jun 2017

Mauger Florence, How-Kit Alexandre, Tost Jörg

Abstract excerpt

Somatic mutations bear great promise for use as biomarkers for personalized medicine, but are often present only in low abundance in biological material and are therefore difficult to detect. Many assays for mutation analysis in cancer-related genes (hotspots) have been developed to improve diagnosis, prognosis, prediction of drug resistance, and monitoring of the response to treatment. Two major approaches have...

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PMID: 28101802
DOI: 10.1007/s40291-016-0254-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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