Article
Identification of ten loci associated with height highlights new biological pathways in human growth.
Nature genetics - 1 May 2008
Lettre Guillaume, Jackson Anne U, Gieger Christian, Schumacher Fredrick R, Berndt Sonja I, Sanna Serena, Eyheramendy Susana, Voight Benjamin F, Butler Johannah L, Guiducci Candace, Illig Thomas, Hackett Rachel, Heid Iris M, Jacobs Kevin B, Lyssenko Valeriya, Uda Manuela, Boehnke Michael, Chanock Stephen J, Groop Leif C, Hu Frank B, Isomaa Bo, Kraft Peter, Peltonen Leena, Salomaa Veikko, Schlessinger David, Hunter David J, Hayes Richard B, Abecasis Gonçalo R, Wichmann H-Erich, Mohlke Karen L, Hirschhorn Joel N
Abstract excerpt
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.