Article
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
PLoS genetics - 1 Apr 2009
Soranzo Nicole, Rivadeneira Fernando, Chinappen-Horsley Usha, Malkina Ida, Richards J Brent, Hammond Naomi, Stolk Lisette, Nica Alexandra, Inouye Michael, Hofman Albert, Stephens Jonathan, Wheeler Eleanor, Arp Pascal, Gwilliam Rhian, Jhamai P Mila, Potter Simon, Chaney Amy, Ghori Mohammed J R, Ravindrarajah Radhi, Ermakov Sergey, Estrada Karol, Pols Huibert A P, Williams Frances M, McArdle Wendy L, van Meurs Joyce B, Loos Ruth J F, Dermitzakis Emmanouil T, Ahmadi Kourosh R, Hart Deborah J, Ouwehand Willem H, Wareham Nicholas J, Barroso Inês, Sandhu Manjinder S, Strachan David P, Livshits Gregory, Spector Timothy D, Uitterlinden André G, Deloukas Panos
Abstract excerpt
Recent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,187 individuals, and identified 17 genomic regions with GW-significant association with height. Of these, two are...
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