Article
A common variant of HMGA2 is associated with adult and childhood height in the general population.
Nature genetics - 1 Oct 2007
Weedon Michael N, Lettre Guillaume, Freathy Rachel M, Lindgren Cecilia M, Voight Benjamin F, Perry John R B, Elliott Katherine S, Hackett Rachel, Guiducci Candace, Shields Beverley, Zeggini Eleftheria, Lango Hana, Lyssenko Valeriya, Timpson Nicholas J, Burtt Noel P, Rayner Nigel W, Saxena Richa, Ardlie Kristin, Tobias Jonathan H, Ness Andrew R, Ring Susan M, Palmer Colin N A, Morris Andrew D, Peltonen Leena, Salomaa Veikko, Davey Smith George, Groop Leif C, Hattersley Andrew T, McCarthy Mark I, Hirschhorn Joel N, Frayling Timothy M
Abstract excerpt
Human height is a classic, highly heritable quantitative trait. To begin to identify genetic variants influencing height, we examined genome-wide association data from 4,921 individuals. Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P = 4 x 10(-8)). HMGA2 is also a strong biological candidate for height, as rare, severe mutations in this gene alter body size in mice...
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