Article
Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.
Obesity (Silver Spring, Md.) - 1 Oct 2014
Stergiakouli Evangelia, Gaillard Romy, Tavaré Jeremy M, Balthasar Nina, Loos Ruth J, Taal Hendrik R, Evans David M, Rivadeneira Fernando, St Pourcain Beate, Uitterlinden André G, Kemp John P, Hofman Albert, Ring Susan M, Cole Tim J, Jaddoe Vincent W V, Davey Smith George, Timpson Nicholas J
Abstract excerpt
OBJECTIVE: Genome-wide association studies (GWAS) of BMI are mostly undertaken under the assumption that "kg/m(2) " is an index of weight fully adjusted for height, but in general this is not true. The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children. METHODS: A GWAS of height-adjusted BMI...
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