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Article

Thioredoxin-Interacting Protein Is a Biomechanical Regulator of Src Activity

11 Feb 2014

Abstract excerpt

RATIONALE: Fluid shear stress differentially regulates endothelial cell stress fiber formation with decreased stress fibers in areas of disturbed flow compared with steady flow areas. Importantly, stress fibers are critical for several endothelial cell functions including cell shape, mechano-signal transduction, and endothelial cell-cell junction integrity. A key mediator of steady flow-induced stress fiber...

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Identifiers

PMID: 24515523
DOI: 10.1161/circresaha.114.301315

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