Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shear stress modulation of smooth muscle cell marker genes in 2-D and 3-D depends on mechanotransduction by heparan sulfate proteoglycans and ERK1/2.

PloS one - 16 Aug 2010

Shi Zhong-Dong, Abraham Giya, Tarbell John M

Abstract excerpt

BACKGROUND: During vascular injury, vascular smooth muscle cells (SMCs) and fibroblasts/myofibroblasts (FBs/MFBs) are exposed to altered luminal blood flow or transmural interstitial flow. We investigate the effects of these two types of fluid flows on the phenotypes of SMCs and MFBs and the unde...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Flavonoids
Share to Heparan Sulfate Proteoglycans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Polysaccharide-Lyases

Share to Stress, Mechanical

Source

Open in PubMed Open full text

Identifiers

PMID: 20808940
DOI: 10.1371/journal.pone.0012196
PMCID: PMC2922372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20808940-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shear stress modulation of smooth muscle cell marker genes in 2-D and 3-D depends on mechanotransduction by heparan sulfate proteoglycans and ERK1/2.PMID 20808940Read ↗

Effects of fluid shear stress on adventitial fibroblast migration: implications for flow-mediated mechanisms of arterialization and intimal hyperplasia.Semantic proximity Read ↗

Fluid Mechanics, Arterial Disease, and Gene ExpressionSemantic proximity Read ↗

Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodelingSemantic proximity Read ↗

Shear Stress Regulates Late EPC Differentiation via Mechanosensitive Molecule-Mediated Cytoskeletal RearrangementSemantic proximity Read ↗

High fluid shear stress prevents atherosclerotic plaque formation by promoting endothelium denudation and synthetic phenotype of vascular smooth muscle cells.Semantic proximity Read ↗

Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress.Semantic proximity Read ↗

FAK- and TGF-β1-dependent biomechanical alterations in microvascular endothelial cells exposed to spatial fluid shear stress gradientsSemantic proximity Read ↗

Mechano-Initiated PIEZO1-VEGFR2 Interaction Governs CD34 <sup>+</sup> Cell Differentiation and Repair in Arteriovenous FistulaSemantic proximity Read ↗

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming.Semantic proximity Read ↗

Mechanobiology in vascular remodelingSemantic proximity Read ↗

Early events in endothelial flow sensingSemantic proximity Read ↗

Shear Difference: Flow Type Dictates Endothelial Flow-Responsive Gene Programs in a 3D-Printed in vitro ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.