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Article

Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity.

Scientific reports - 11 Feb 2014

Bülow Margret H, Bülow Torsten R, Hoch Michael, Pankratz Michael J, Jünger Martin A

Abstract excerpt

Biochemical experiments in mammalian cells have linked Src family kinase activity to the insulin signaling pathway. To explore the physiological link between Src and a central insulin pathway effector, we investigated the effect of different Src signaling levels on the Drosophila transcription factor dFOXO in vivo. Ectopic activation of Src42A in the starved larval fatbody was sufficient to drive dFOXO out of the...

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PMID: 24513978
DOI: 10.1038/srep04048
PMCID: PMC3920272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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