Article
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.
Aging cell - 1 Sept 2009
Wessells Robert, Fitzgerald Erin, Piazza Nicole, Ocorr Karen, Morley Samantha, Davies Claire, Lim Hui-Ying, Elmén Lisa, Hayes Michael, Oldham Sean, Bodmer Rolf
Abstract excerpt
dTOR (target of rapamycin) and dFoxo respond to changes in the nutritional environment to induce a broad range of responses in multiple tissue types. Both dTOR and dFoxo have been demonstrated to control the rate of age-related decline in cardiac function. Here, we show that the Eif4e-binding protein (d4eBP) is sufficient to protect long-term cardiac function against age-related decline and that up-regulation of...
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