Article
dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling.
Current biology : CB - 26 Oct 2010
Francis Víctor A, Zorzano Antonio, Teleman Aurelio A
Abstract excerpt
BACKGROUND: Mammalian DOR was discovered as a gene whose expression is misregulated in muscle of Zucker diabetic rats. Because no DOR loss-of-function mammalian models are available, we analyze here the in vivo function of DOR by studying flies mutant for Drosophila DOR (dDOR). RESULTS: We show that dDOR is a novel coactivator of ecdysone receptor (EcR) that is needed during metamorphosis. dDOR binds EcR and is...
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