Article
Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance
25 Jun 2013
Abstract excerpt
A tumour is a heterogeneous population of cells that competes for limited resources. In the clinic, we typically probe the tumour by biopsy, and then characterize it by the dominant genetic clone. But genotypes are only the first link in the chain of hierarchical events that leads to a specific cell phenotype. The relationship between genotype and phenotype is not simple, and the so-called genotype to phenotype...
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