Article
Mix and Match: Phenotypic Coexistence as a Key Facilitator of Cancer Invasion.
Bulletin of mathematical biology - 17 Jan 2020
Strobl Maximilian A R, Krause Andrew L, Damaghi Mehdi, Gillies Robert, Anderson Alexander R A, Maini Philip K
Abstract excerpt
Invasion of healthy tissue is a defining feature of malignant tumours. Traditionally, invasion is thought to be driven by cells that have acquired all the necessary traits to overcome the range of biological and physical defences employed by the body. However, in light of the ever-increasing evidence for geno- and phenotypic intra-tumour heterogeneity, an alternative hypothesis presents itself: could invasion be...
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