Article
Detection of MYD88 L265P in peripheral blood of patients with Waldenström's Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.
Leukemia - 1 Aug 2014
Xu L, Hunter Z R, Yang G, Cao Y, Liu X, Manning R, Tripsas C, Chen J, Patterson C J, Kluk M, Kanan S, Castillo J, Lindeman N, Treon S P
Abstract excerpt
MYD88 L265P is highly prevalent in Waldenstrom's Macroglobulinemia (WM) and IgM monoclonal gammopathy of unknown significance (MGUS). We investigated whether MYD88 L265P could be identified by peripheral blood (PB) allele-specific PCR. MYD88 L265P was detected in untreated WM (114/118; 96.6%); previously treated WM (63/102; 61.8%); and IgM MGUS (5/12; 41.7%) but in none of 3 hyper-IgM or 40 healthy individuals....
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