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Article

MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.

The New England journal of medicine - 30 Aug 2012

Treon Steven P, Xu Lian, Yang Guang, Zhou Yangsheng, Liu Xia, Cao Yang, Sheehy Patricia, Manning Robert J, Patterson Christopher J, Tripsas Christina, Arcaini Luca, Pinkus Geraldine S, Rodig Scott J, Sohani Aliyah R, Harris Nancy Lee, Laramie Jason M, Skifter Donald A, Lincoln Stephen E, Hunter Zachary R

Abstract excerpt

BACKGROUND: Waldenström's macroglobulinemia is an incurable, IgM-secreting lymphoplasmacytic lymphoma (LPL). The underlying mutation in this disorder has not been delineated. METHODS: We performed whole-genome sequencing of bone marrow LPL cells in 30 patients with Waldenström's macroglobulinemia, with paired normal-tissue and tumor-tissue sequencing in 10 patients. Sanger sequencing was used to validate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22931316
DOI: 10.1056/NEJMoa1200710

Genes

LPL
MYD88

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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