Article
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Blood - 14 Mar 2013
Xu Lian, Hunter Zachary R, Yang Guang, Zhou Yangsheng, Cao Yang, Liu Xia, Morra Enrica, Trojani Alessandra, Greco Antonino, Arcaini Luca, Varettoni Marzia, Varettoni Maria, Brown Jennifer R, Tai Yu-Tzu, Anderson Kenneth C, Munshi Nikhil C, Patterson Christopher J, Manning Robert J, Tripsas Christina K, Lindeman Neal I, Treon Steven P
Abstract excerpt
By whole-genome and/or Sanger sequencing, we recently identified a somatic mutation (MYD88 L265P) that stimulates nuclear factor κB activity and is present in >90% of Waldenström macroglobulinemia (WM) patients. MYD88 L265P was absent in 90% of immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) patients. We therefore developed conventional and real-time allele-specific polymerase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.