Article
MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenström's macroglobulinemia.
Leukemia - 1 Aug 2013
Jiménez C, Sebastián E, Chillón M C, Giraldo P, Mariano Hernández J, Escalante F, González-López T J, Aguilera C, de Coca A G, Murillo I, Alcoceba M, Balanzategui A, Sarasquete M E, Corral R, Marín L A, Paiva B, Ocio E M, Gutiérrez N C, González M, San Miguel J F, García-Sanz R
Abstract excerpt
We evaluated the MYD88 L265P mutation in Waldenström's macroglobulinemia (WM) and B-cell lymphoproliferative disorders by specific polymerase chain reaction (PCR) (sensitivity ∼10(-3)). No mutation was seen in normal donors, while it was present in 101/117 (86%) WM patients, 27/31 (87%) IgM monoclonal gammapathies of uncertain significance (MGUS), 3/14 (21%) splenic marginal zone lymphomas and 9/48 (19%)...
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