Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYD88 Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies.

International journal of molecular sciences - 16 May 2022

Alcoceba Miguel, García-Álvarez María, Medina Alejandro, Maldonado Rebeca, González-Calle Verónica, Chillón María Carmen, Sarasquete María Eugenia, González Marcos, García-Sanz Ramón, Jiménez Cristina

Abstract excerpt

The MYD88 gene has a physiological role in the innate immune system. Somatic mutations in MYD88, including the most common L265P, have been associated with the development of certain types of lymphoma. MYD88L265P is present in more than 90% of patients with Waldenström's macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (IgM-MGUS). The absence of MYD88 mutations in WM patients has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Lymphoma

Share to Lymphoma, B-Cell

Share to Mutation

Share to Myeloid Differentiation Factor 88

Share to Waldenstrom Macroglobulinemia

Source

Open in PubMed Open full text

Identifiers

PMID: 35628381
DOI: 10.3390/ijms23105570
PMCID: PMC9141891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYD88 Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies.PMID 35628381Read ↗

MYD88 and beyond: novel opportunities for diagnosis, prognosis and treatment in Waldenström's Macroglobulinemia.Semantic proximity Read ↗

MYD88 L265P mutation in Waldenstrom macroglobulinemia.Semantic proximity Read ↗

MYD88 wild-type Waldenstrom Macroglobulinaemia: differential diagnosis, risk of histological transformation, and overall survival.Semantic proximity Read ↗

MYD88 gene and protein: molecular architecture, signalling mechanisms and clinical implications in lymphoid malignancies.Semantic proximity Read ↗

Role of MYD88 in lymphoplasmacytic lymphoma diagnosis and pathogenesis.Semantic proximity Read ↗

Novel approaches to targeting MYD88 in Waldenström macroglobulinemia.Semantic proximity Read ↗

MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

Significances of MYD88L265P and CXCR4WHIM Mutations in Waldenstrom Macroglobulinemia.Semantic proximity Read ↗

Detection of MYD88 L265P in peripheral blood of patients with Waldenström's Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.Semantic proximity Read ↗

MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.Semantic proximity Read ↗

Diagnostic Next-generation Sequencing Frequently Fails to Detect MYD88L265P in Waldenström MacroglobulinemiaSemantic proximity Read ↗

Detection of MYD88 L265P and WHIM-like CXCR4 mutation in patients with IgM monoclonal gammopathy related disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.