Article
MYD88 L265P mutation in Waldenstrom macroglobulinemia.
Blood - 30 May 2013
Poulain Stéphanie, Roumier Christophe, Decambron Audrey, Renneville Aline, Herbaux Charles, Bertrand Elisabeth, Tricot Sabine, Daudignon Agnès, Galiègue-Zouitina Sylvie, Soenen Valerie, Theisen Olivier, Grardel Nathalie, Nibourel Olivier, Roche-Lestienne Catherine, Quesnel Bruno, Duthilleul Patrick, Preudhomme Claude, Leleu Xavier
Abstract excerpt
Mutation of the MYD88 gene has recently been identified in activated B-cell-like diffuse cell lymphoma and enhanced Janus kinase/signal transducer and activator of transcription (JAK-STAT) and nuclear factor κB (NF-κB) signaling pathways. A whole exome-sequencing study of Waldenstrom macroglobulinemia (WM) suggested a high frequency of MYD88 L265P mutation in WM. The genetic background is not fully deciphered in...
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