APOE, TOMM40, and sex interactions on neural network connectivity.

doi:10.1016/j.neurobiolaging.2021.09.020

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Article

APOE, TOMM40, and sex interactions on neural network connectivity.

Neurobiology of aging - 1 Jan 2022

Li Tianqi, Pappas Colleen, Le Scott T, Wang Qian, Klinedinst Brandon S, Larsen Brittany A, Pollpeter Amy, Lee Ling Yi, Lutz Mike W, Gottschalk William K, Swerdlow Russell H, Nho Kwangsik, Willette Auriel A

Abstract excerpt

The Apolipoprotein E ε4 (APOE ε4) haplotype is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). The Translocase of Outer Mitochondrial Membrane-40 (TOMM40) gene maintains cellular bioenergetics, which is disrupted in AD. TOMM40 rs2075650 ('650) G versus A carriage is consistently related to neural and cognitive outcomes, but it is unclear if and how it interacts with APOE. We examined 21...

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PMID: 34740077
DOI: 10.1016/j.neurobiolaging.2021.09.020
PMCID: PMC8694046

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