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Article

The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition.

The FEBS journal - 1 Nov 2016

Lubbe Lizelle, Sewell Brian T, Sturrock Edward D

Abstract excerpt

Angiotensin-1-converting enzyme (ACE) is a zinc metalloprotease that plays a major role in blood pressure regulation via the renin-angiotensin-aldosterone system. ACE consists of two domains with differences in inhibitor binding affinities despite their 90% active site identity. While the C-domain primarily controls blood pressure, the N-domain is selective for cleavage of the antifibrotic...

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Identifiers

PMID: 27636235
DOI: 10.1111/febs.13900

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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