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Directed evolution of angiotensin-converting enzyme 2 (ACE2) peptidase activity profiles for therapeutic applications

2022-01-03

Abstract excerpt

Angiotensin Converting-Enzyme 2 (ACE2) is currently being investigated for its ability to beneficially modulate the Angiotensin receptor (ATR) therapeutic axis to treat multiple human diseases, but its broad substrate scope and diverse physiological roles limit its potential as a therapeutic agent. In this work we engineer ACE2 variants with enhanced hydrolytic activity and specificity toward Angiotensin-II (Ang-I...

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Literature Corpus work
b2776a8c-f1d9-5f8b-afa9-3ca58b2da339
DOI
10.1101/2022.01.03.474817
Open publication

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Directed evolution of angiotensin-converting enzyme 2 (ACE2) peptidase activity profiles for therapeutic applicationsDOI 10.1101/2022.01.03.474817
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