Article
Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding.
Scientific reports - 13 Oct 2016
Danilov Sergei M, Lünsdorf Heinrich, Akinbi Henry T, Nesterovitch Andrew B, Epshtein Yuliya, Letsiou Eleftheria, Kryukova Olga V, Piegeler Tobias, Golukhova Elena Z, Schwartz David E, Dull Randal O, Minshall Richard D, Kost Olga A, Garcia Joe G N
Abstract excerpt
Angiotensin I-converting enzyme (ACE) hydrolyzes numerous peptides and is a critical participant in blood pressure regulation and vascular remodeling. Elevated tissue ACE levels are associated with increased risk for cardiovascular and respiratory disorders. Blood ACE concentrations are determined by proteolytic cleavage of ACE from the endothelial cell surface, a process that remains incompletely understood. In...
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