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Article

The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.

The Biochemical journal - 1 Aug 2005

Woodman Zenda L, Schwager Sylva L U, Redelinghuys Pierre, Carmona Adriana K, Ehlers Mario R W, Sturrock Edward D

Abstract excerpt

sACE (somatic angiotensin-converting enzyme) consists of two homologous, N and C domains, whereas the testis isoenzyme [tACE (testis ACE)] consists of a single C domain. Both isoenzymes are shed from the cell surface by a sheddase activity, although sACE is shed much less efficiently than tACE. We hypothesize that the N domain of sACE plays a regulatory role, by occluding a recognition motif on the C domain...

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Source

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Identifiers

PMID: 15813703
DOI: 10.1042/BJ20050187
PMCID: PMC1180724

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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