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Article

Interleukin-6 receptor blockade enhances CD39+ regulatory T cell development in rheumatoid arthritis and in experimental arthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2014

Thiolat A, Semerano L, Pers Y M, Biton J, Lemeiter D, Portales P, Quentin J, Jorgensen C, Decker P, Boissier M-C, Louis-Plence P, Bessis N

Abstract excerpt

OBJECTIVE: The rationale for blocking interleukin-6 (IL-6) in rheumatoid arthritis (RA) lies chiefly in the proinflammatory effect of this cytokine. Few studies have evaluated the consequences of anti-IL-6 receptor (IL-6R) antibody treatment on Treg cells. This study was undertaken to elucidate the mechanism of action of anti-IL-6R antibody treatment by studying the effects on Treg cells in an experimental...

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Share to Antibodies, Anti-Idiotypic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Arthritis, Experimental

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Share to Receptors, Interleukin-6

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Source

Identifiers

PMID: 24504799
DOI: 10.1002/art.38246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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