Article

Inhibition of TGF-β Signaling Suppresses Th17 Differentiation and Promotes Treg Numbers but does not Reduces Experimental Arthritis

2021-10-01

Abstract excerpt

<h4>Objectives: </h4> TGF-β is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β as therapeutic target in T cell-mediated diseases like rheumatoid arthritis (RA) is unclear. We investigated the effect of TGF-β inhibition on murine Th17 differentiation in vitro , on human RA synovial explants ex vivo , and on the development of expe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e8787d1-c37b-582f-bc38-62789d1fd20c
DOI: 10.21203/rs.3.rs-908009/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of TGF-β Signaling Suppresses Th17 Differentiation and Promotes Treg Numbers but does not Reduces Experimental ArthritisDOI 10.21203/rs.3.rs-908009/v1Read

Inhibition of TGF-β Signaling Suppresses Th17 Differentiation and Promotes Treg Numbers but Does Not Reduce Experimental Arthritis.Semantic proximity Read

Mechanism underlying the action of Duanteng-Yimu Tang in regulating Treg/Th17 imbalance and anti-rheumatoid arthritisSemantic proximity Read

Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis.Semantic proximity Read

Selective Immune Silencing by Targeted TGF-β AgonistsSemantic proximity Read

The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiationSemantic proximity Read

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivoSemantic proximity Read

Interleukin-6 receptor blockade enhances CD39+ regulatory T cell development in rheumatoid arthritis and in experimental arthritis.Semantic proximity Read

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivoSemantic proximity Read

TGF-β Isoforms and Receptors: A Gene Expression Analysis in Multiple Sclerosis Patients and Normal IndividualsSemantic proximity Read

In Vitro Th Differentiation Protocol.Semantic proximity Read

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cellsSemantic proximity Read

Mouse T helper 17 phenotype: not so different than in man after all.Semantic proximity Read