Article

Inhibition of TGF-β Signaling Suppresses Th17 Differentiation and Promotes Treg Numbers but Does Not Reduce Experimental Arthritis.

2021-09-08

Abstract excerpt

<title>Abstract</title> <p><bold>Objectives</bold>TGF-β is an important growth factor to promote the differentiation of T helper 17 (Th17) as well as regulatory T cells (Treg). Due to its dual role, the potential of TGF-β as therapeutic target in T cell-mediated diseases like rheumatoid arthritis (RA) is unclear. In this study, we investigated the effect of TGF-β inhibition on murine Th17 differentiation <italic>...

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Literature Corpus work: 3ef9b525-7f43-5f31-b5fc-310c605ccade
DOI: 10.21203/rs.3.rs-840399/v1

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