Article
CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid.
Arthritis and rheumatism - 1 Sept 2004
van Amelsfort Jocea M R, Jacobs Kim M G, Bijlsma Johannes W J, Lafeber Floris P J G, Taams Leonie S
Abstract excerpt
OBJECTIVE: In mice, CD4(+)CD25(+) regulatory T cells play a pivotal role in preventing autoimmunity. Regulatory T cells are also present and functional in healthy humans. We investigated the presence, phenotype, and function of CD4(+)CD25(+) regulatory T cells in peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA). METHODS: The presence and phenotype of CD4(+)CD25(+)...
Topics
- Adult
- Arthritis, Rheumatoid
- Autoimmunity
- Blood
- CD4-Positive T-Lymphocytes
- Feedback, Physiological
- Female
- Humans
- In Vitro Techniques
- Lymphocyte Activation
- Male
- Middle Aged
- Phenotype
- Receptors, Interleukin-2