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Article

B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis.

PloS one - 1 Jan 2017

Moura Rita A, Quaresma Cláudia, Vieira Ana R, Gonçalves Maria J, Polido-Pereira Joaquim, Romão Vasco C, Martins Nádia, Canhão Helena, Fonseca João E

Abstract excerpt

BACKGROUND: The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene expression in RA. METHODS: Blood samples were collected from untreated early RA (ERA) patients, established RA patients...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28886017
DOI: 10.1371/journal.pone.0182927
PMCID: PMC5590747

Genes

TNF
CXCL13
TLR9
CXCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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