IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8+ T cells

Abstract excerpt

We propose a novel role for interleukin (IL) 6 in inducing rapid spontaneous proliferation (SP) of naive CD8(+) T cells, which is a crucial step in the differentiation of colitogenic CD8(+) T cells. Homeostasis of T cells is regulated by two distinct modes of cell proliferation: major histocompatibility complex/antigen-driven rapid SP and IL-7/IL-15-dependent slow homeostatic proliferation. Using our novel model...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammatory Bowel Disease
• Share to Microscopic Colitis
• Share to Psoriasis: Treatment and Pathogenesis