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Article

Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.

Endocrinology - 1 Mar 2014

Kennedy Oran D, Sun Hui, Wu Yingjie, Courtland Hayden-William, Williams Garry A, Cardoso Luis, Basta-Pljakic Jelena, Schaffler Mitchell B, Yakar Shoshana

Abstract excerpt

IGF-I is a critical regulator of skeletal acquisition, which acts in endocrine and autocrine/paracrine modes. In serum, IGF-I is carried by the IGF-binding proteins in binary complexes. Further stabilization of these complexes is achieved by binding to the acid labile subunit (ALS) in a ternary complex (of IGF-I-IGF-binding protein 3/5-ALS). Ablation of the Igfals gene in humans (ALS deficiency) and mice (ALS...

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Identifiers

PMID: 24424061
DOI: 10.1210/en.2013-1819
PMCID: PMC3929729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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