Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease

4 Feb 2014

Abstract excerpt

Huntington's disease (HD) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. HD is clinically characterized by chorea, emotional and psychiatric disturbances and cognitive deficits with later symptoms including rigidity and dementia. Pathologically, the cortico-striatal pathway is severely dysfunctional as reflected by striatal and cortical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Nerve injury and regeneration
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24503862
DOI: 10.1371/journal.pone.0087923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s DiseasePMID 24503862Read ↗

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.Semantic proximity Read ↗

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brainSemantic proximity Read ↗

PET Ligands for Imaging Mutant Huntingtin Aggregates: A Case Study in Non-For-Profit Scientific Management.Semantic proximity Read ↗

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidatesSemantic proximity Read ↗

Targeting mutant huntingtin for the development of disease-modifying therapy.Semantic proximity Read ↗

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Semantic proximity Read ↗

Amitriptyline Improves Motor Function via Enhanced Neurotrophin Signaling and Mitochondrial Functions in the Murine N171-82Q Huntington Disease ModelSemantic proximity Read ↗

Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice StudiesSemantic proximity Read ↗

Neurotrophins and neurodegenerationSemantic proximity Read ↗

Huntington's disease.Semantic proximity Read ↗

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s DiseaseSemantic proximity Read ↗

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.