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Article

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.

BMC biochemistry - 25 Nov 2013

Massai Luisa, Petricca Lara, Magnoni Letizia, Rovetini Luca, Haider Salman, Andre Ralph, Tabrizi Sarah J, Süssmuth Sigurd D, Landwehrmeyer Bernhard G, Caricasole Andrea, Pollio Giuseppe, Bernocco Simonetta

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, with its levels most likely related to disease progression and symptom severity. Since non-invasive methods to quantify HTT in the CNS do not exist, measuring amount of soluble HTT in...

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Source

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Identifiers

PMID: 24274906
DOI: 10.1186/1471-2091-14-34
PMCID: PMC4221641

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.PMID 24274906Read ↗

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