Article

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s Disease

2023-05-09

Abstract excerpt

<h4>SUMMARY</h4> Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult cortex and hippocampus in rodents, primates and humans, with adult NSC differentiation sharing key regulatory mechanisms with development. Adult neurogenesis impairments have been linked to Alzheimer’s Disease (AD) pathology....

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Literature Corpus work: 8aec5af1-9606-56d2-b910-6c591c264817
DOI: 10.1101/2023.05.08.539797

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