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Article

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

1 Feb 2006

Abstract excerpt

Deficits of neurotrophic support caused by reduced levels of brain-derived neurotrophic factor (BDNF) have been implicated in the selective vulnerability of striatal neurones in Huntington's disease (HD). Therapeutic strategies based on BDNF administration have been proposed to slow or prevent the disease progression. However, the effectiveness of BDNF may depend on the proper expression of its receptor TrkB. In...

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PMID: 16487146
DOI: 10.1111/j.1460-9568.2006.04590.x

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