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Article

Accelerated aging exacerbates a pre‐existing pathology in a tau transgenic mouse model

4 Feb 2017

Abstract excerpt

Age is a critical factor in the prevalence of tauopathies, including Alzheimer's disease. To observe how an aging phenotype interacts with and affects the pathological intracellular accumulation of hyperphosphorylated tau, the tauopathy mouse model pR5 (expressing P301L mutant human tau) was back-crossed more than ten times onto a senescence-accelerated SAMP8 background to establish the new strain, SApT. Unlike...

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PMID: 28160413
DOI: 10.1111/acel.12565

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