Article

Gelsolin Counteracts ER Stress-Driven Inflammatory Circuits in Psoriasis-like Dermatitis

2025-11-21

Abstract excerpt

Psoriasis is a chronic inflammatory skin disorder driven by amplified communication between immune cells and keratinocytes. Here, we show that imiquimod (IMQ) triggers organelle stress responses that directly contribute to this pathogenic circuit. In dendritic cells (DCs), IMQ promotes formation of ER–mitochondria contact sites (MAMs), inducing ER stress and activation of the unfolded protein response (UPR). These...

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Literature Corpus work: 73c17dba-705e-5580-93a3-ad7eeb5bea57
DOI: 10.1101/2025.11.20.689413

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