Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation

1 Jan 2025

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by an impaired epidermal barrier and immunological alterations. The activity of the cytoprotective NRF2 transcription factor is reduced in the epidermis of AD patients. To determine the functional relevance of this deficiency, we used mice lacking fibroblast growth factor receptors 1 and 2 in keratinocytes (K5-R1/R2 mice), which exhibit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Dermatology and Skin Diseases
Share to Genomics, phytochemicals, and oxidative stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39744884
DOI: 10.1242/dmm.052126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammationPMID 39744884Read ↗

The Role of KEAP1-NRF2 System in Atopic Dermatitis and PsoriasisSemantic proximity Read ↗

AHR and NRF2 in Skin Homeostasis and Atopic DermatitisSemantic proximity Read ↗

NRF2 Augments Epidermal Antioxidant Defenses and Promotes AtopySemantic proximity Read ↗

Nrf2—A regulator of keratinocyte redox signalingSemantic proximity Read ↗

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.Semantic proximity Read ↗

Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis.Semantic proximity Read ↗

Induction of skin sensitization is augmented in Nrf2-deficient miceSemantic proximity Read ↗

NRF2 in neurodegenerative diseasesSemantic proximity Read ↗

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in miceSemantic proximity Read ↗

Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic DermatitisSemantic proximity Read ↗

Oxidative Stress in Atopic Dermatitis.Semantic proximity Read ↗

Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.